Insurance coverage
UnitedHealthcare + Optum
United covers Spravato for TRD through Optum Behavioral Health. Prior authorization is required and Optum runs a concurrent review. IV ketamine is generally not covered except where your employer has added it as a supplemental benefit.
Coverage at a glance
| Modality | Status |
|---|---|
| Spravato (esketamine) | Covered |
| Ketamine IV infusion | Not covered |
| Ketamine IM injection | Not covered |
| Ketamine oral/lozenge | Not covered |
| Psilocybin (Oregon licensed) | Not covered |
| Psilocybin (Colorado licensed) | Not covered |
What the plan requires
- Two failed antidepressant trials.
- Optum Behavioral prior auth.
- REMS site participation.
Practical tips
- Optum Rx is the pharmacy side. Some employers carve out behavioral to a different vendor.
- UnitedHealthcare Community Plan (Medicaid) coverage varies by state.
Providers accepting UnitedHealthcare
Always confirm in-network status with both the clinic and your plan before your first session.
Greenbrook TMS NeuroHealth - Buffalo
Buffalo, NY
Greenbrook operates 130+ Spravato REMS-certified treatment centers across the US. Buffalo location observes patients for the full 2-hour post-dose REMS monitoring window in private recovery suites.
Salience Neuro Health - Austin
Austin, TX
Dual-modality Spravato and IV ketamine provider. Covered by most commercial plans for Spravato when treatment-resistant depression criteria are met. Board-certified anesthesiologist on staff.
Principium Psychiatry
New York, NY
Midtown Manhattan psychiatry practice specializing in treatment-resistant depression. Spravato REMS-certified since 2019. Also offers IV ketamine and interventional psychiatry (TMS).
California Center for TMS - Beverly Hills
Beverly Hills, CA
Interventional psychiatry practice offering Spravato esketamine alongside TMS. Accepts most major commercial plans and Medicare. Separate recovery lounges for post-dose observation.
Actify Neurotherapies
Chevy Chase, MD
Washington DC metro ketamine and Spravato clinic operating since 2012. One of the longest-running interventional psychiatry practices in the mid-Atlantic.
Bloom Ketamine
Denver, CO
Denver Capitol Hill ketamine clinic. Dual IV/Spravato offering means insurance-billable Spravato for TRD patients alongside out-of-pocket ketamine alternatives.
Ember Mental Health
Chicago, IL
Loop-area interventional psychiatry clinic. Spravato covered under most Illinois BCBS, Aetna, and UnitedHealthcare plans after step therapy documentation.
Liminal Psychiatry
Boston, MA
Back Bay interventional psychiatry practice. Board-certified psychiatrists, separate IV ketamine and Spravato tracks. Part of the Mass General Brigham referral network.
Lucidity Health
Portland, OR
Portland interventional psychiatry clinic. Oregon Medicaid (OHP) accepted for Spravato when TRD criteria are met - one of few clinics in the Pacific Northwest doing Medicaid billing.
New Pathways Psychiatry
Philadelphia, PA
Philadelphia psychiatry group. Accepts PA Medicaid (Keystone First, AmeriHealth Caritas, UPMC For You) for Spravato - rare in the region.