Head to head
Ketamine IV vs Psilocybin CO
A side-by-side look at Ketamine IV infusion and Psilocybin (Colorado licensed) across the factors that actually change your decision: cost, setting, insurance, evidence, and the kind of clinician who runs the room.
Factor
Ketamine IV
Psilocybin CO
Legal status
Off-label (state boards + DEA)
State-licensed (CO Prop 122)
Setting
Clinic, continuous monitoring
Licensed healing center, 6-8hr
Session length
60-90 min
6-8 hours
Insurance coverage
Rare (Anthem, Empire BCBS)
Not covered
Typical cost / session
$400-$600
$2,200-$3,500
Induction / course
6 sessions over 2-3 weeks
1-3 sessions
Evidence base
Strongest off-label evidence for TRD
Phase 2b + observational data
Who administers
Anesthesiologist, psychiatrist or CRNA
Licensed DORA facilitator
Risk of abuse / dependency
Low in monitored setting
No take-home; minimal abuse liability
Verified Ketamine IV providers
18
Verified Psilocybin CO providers
3