Head to head
Spravato vs Psilocybin OR
A side-by-side look at Spravato (esketamine) and Psilocybin (Oregon licensed) across the factors that actually change your decision: cost, setting, insurance, evidence, and the kind of clinician who runs the room.
Factor
Spravato
Psilocybin OR
Legal status
FDA-approved 2019
State-licensed (OR Measure 109)
Setting
REMS-certified site, 2-hour observation
Licensed service center, 6-8hr
Session length
~2.5 hours
6-8 hours
Insurance coverage
Commonly covered for TRD
Not covered
Typical cost / session
$0-$950 (insurance-dependent)
$2,200-$3,500
Induction / course
8 sessions over 4 weeks
1-3 sessions
Evidence base
Phase 3 RCTs; FDA approved
Phase 2b + observational data
Who administers
Psychiatrist / nurse practitioner at REMS site
Licensed OHA facilitator
Risk of abuse / dependency
Schedule III, REMS-controlled
No take-home; minimal abuse liability
Verified Spravato providers
12
Verified Psilocybin OR providers
8