Head to head
Ketamine IM vs Psilocybin CO
A side-by-side look at Ketamine IM injection and Psilocybin (Colorado licensed) across the factors that actually change your decision: cost, setting, insurance, evidence, and the kind of clinician who runs the room.
Factor
Ketamine IM
Psilocybin CO
Legal status
Off-label (state boards + DEA)
State-licensed (CO Prop 122)
Setting
Clinic, on-site observation
Licensed healing center, 6-8hr
Session length
60-90 min
6-8 hours
Insurance coverage
Rare
Not covered
Typical cost / session
$300-$450
$2,200-$3,500
Induction / course
6 sessions over 2-3 weeks
1-3 sessions
Evidence base
Emerging, comparable to IV in small trials
Phase 2b + observational data
Who administers
Psychiatrist or NP with monitoring
Licensed DORA facilitator
Risk of abuse / dependency
Low in monitored setting
No take-home; minimal abuse liability
Verified Ketamine IM providers
11
Verified Psilocybin CO providers
3